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Personal Details

Designation : Assistant Professor Department : Biological Sciences E-Mail : sanjeevs@iiserb.ac.in Phone : +91-755-4092300 Fax : +91-755-4092392



Academic Details


  • Assistant Professor (May 2013-): Biological Sciences, Indian Institute of Science, Education and Research (IISER) Bhopal

  • Postdoctoral Fellow (March 2010-March 2013): National Cancer Institute, National Institutes of Health, Maryland, USA

  • Postdoctoral Fellow (May 2009-Feb 2010): Georgetown University Medical Centre, Washington DC, USA

  • Ph.D. (Nov 2003-Feb 2009): Advanced Centre for Treatment, Research and Education in Cancer (CRI-ACTREC), Navi Mumbai

    Research Interests: Epigenetics and RNA Processing


    Interplay between epigenetic changes and alternative pre-mRNA splicing in tumorigenesis


    • -Examination of DNA methylation mediated regulation of alternative splicing via modulation of reciprocal binding of CTCF and BORIS in cancer cells.

    • -Analysis of DNA binding proteins/ transcription factors and upstream pathways that are involved in regulation of alternative splicing

    • -Examination of role of cancer specific alternative spliced isoforms in tumorigenesis

    Publications


    • -Shukla S, Govekar RB, Sirdeshmukh R, Sundaram CS, D’Cruz A, Pathak KA, Kane SV, Zingde SM Tumor antigens eliciting autoantibody response in cancer of gingivo-buccal complex. Proteomics Clinical Applications 2007, 1(12): 1592-1604.

    • -Shukla S, Pranay A, D’Cruz AK, Chaturvedi P, Kane SV, Zingde SM “Immunoproteomics reveals that cancer of the tongue and the gingivo buccal complex exhibit differential autoantibody response.” Cancer Biomarkers 2009, 5(3): 127-35.

    • Received F1000 article factor (FFa) -17 (exceptional rating) from Faculty of 1000 based on following 4 evaluations. http://f1000.com/13371987

    • This article was also highlighted in CCR connections Vol 6 (1), 2012 “CTCF, a Novel Regulator of Alternative Splicing” http://home.ccr.cancer.gov/connections/ dev/2012/Vol6_No1/news_7.asp

    • This article was highlighted in Cell Research- Kornblihtt A. “CTCF: from insulators to alternative splicing regulation”, Cell Research advance online publication 7 February 2012; doi:10.1038/cr.2012.22 http://www.nature.com/cr/journal/vaop/ncurrent/full/cr201222a.html

    • -Shukla S, Kavak E, Gregory M, Imashimizu M, Shutinoski B, Kashlev M, Oberdoerffer P, Sandberg R, Oberdoerffer S. “CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing”. Nature 479, 74–79 (03 November 2011).

    • -Shukla S., Oberdoerffer S. Co-transcriptional regulation of alternative pre- mRNA splicing. BBA-Gene Regulatory Mechanism July 2012, 1819 (7), 673- 683.

    • -Pranay A, Shukla S et al. Prognostic utility of autoantibodies to α-enolase and Hsp70 for cancer of the gingivo-buccal complex using immunoproteomics. Proteomics Clinical Applications 2012; DOI: 10.1002/prca.201200081.

    Patent


    • Zingde, Shukla, Sirdeshmukh, Sundaram D’Cruz, Pathak, Kane [Inventors] Autoantibodies for protein antigens as markers for cancer of the ginigivo –buccal complex:

      CSIR: Ref No: 0187NF 2006/1N, filed on Feb 14, 2007; 290DEL 2007
      European Patent Application EP2126578 (Published: Feb 12, 2009)
      US application- US 2011/0189699A1 (published: date Aug 04, 2011)

    Open positions


      • I am looking for postdoctoral candidate who is interested to study epigenetic regulation of alternative pre-mRNA splicing/RNA processing in tumorigenesis. Interested candidate can send their cv and statement of research interest by email to me at sanjeevs@iiserb.ac.in

        Epigibility: Candidate should have PhD in biological sciences from recognized university/institution.

        Desirable: Prior experience with molecular biology techniques. Candidates with experience in analysis of next-generation sequencing data/ RNA work / chromatin biology are encouraged to apply.

    PhD Student


    • Smriti Singh

      smritis@iiserb.ac.in